Original Articles

Nina Reiter; Beate Eichelberger; Alexandra Kaider; Simon Panzer
Thrombin-inducible platelet adhesion and regulation of the platelet seven-transmembrane thrombin receptor-1 (PAR-1): Effects of unfractionated heparin and lepirudin
Platelets (2009) 20: 8, 582 - 587

A.M. Albanyan, M.F. Murphy, P. Harrison
Evaluation of the Impact-R for monitoring the platelet storage lesion
Platelets (2009) February 20 (1), 1–6

G. Gouya, B. Jilma, M. Niel, B. Eichelberger, M. Wolzt, S. Panzer
Cross validation of aspirin effect in healthy individuals by Impact-R and PFA-100:
A double blind randomized placebo controlled trial
Platelets, (2009) May 20 (3), 171-176

Tal Bouganim, Yaron Shapira, Alexander Sagie, Mordehay Vaturi, Alexander Battler, Ran Kornowski, Eli I. Lev
Platelet Reactivity in Patients With a History of Obstructive Prosthetic Valve Thrombosis
American Journal Cardiology, (2009) 103, 1760 –1763

Thomas Gremmel, Sabine Steiner, Daniela Seidinger, Renate Koppensteiner, Simon Panzer, Christoph W. Kopp
Comparison of methods to evaluate clopidogrel-mediated platelet inhibition after percutaneous intervention with stent implantation
Thrombosis and Haemostasis (2009) 101, 333–339

Julie H. Oestreich; Susan S. Smyth; Charles L. Campbell
Platelet function analysis: At the edge of meaning
Thromb Haemost (2009) 101: 217–219

Shlomi Matetzky, Paul Fefer, Boris Shenkman, David Varon, Naphtali Savion, Hanoch Hod
Effectiveness of Reloading to Overcome Clopidogrel Nonresponsiveness in Patients With Acute Myocardial Infarction
Am J Cardiol (2008) 102:524 –529

Neta Goldschmidt, Galia Spectre, Alexander Brill, Orly Zelig, Ada Goldfarb, Eliezer Rachmilewitz, David Varon
Increased platelet adhesion under flow conditions is induced by both thalassemic platelets and red blood cells
Thrombosis and Haemostasis (2008) 100, No.5: 864-870.

B. Shenkman, Y. Einav, O. Salomon, D. Varon, N. Savion,
Testing agonist-induced platelet aggregation by the Impact-R [Cone and plate(let) analyzer (CPA)]
Platelets (2008) 19: 6,440 — 446

Boris Shenkman, Shlomi Matetzky, Paul Fefer, Hanoch Hod, Yulia Einav, Aharon Lubetsky, David Varon, Naphtali Savion
Variable responsiveness to clopidogrel and aspirin among patients with acute coronary syndrome as assessed by platelet function tests
Thrombosis Research (2008) 122, 336–345

Schwammenthal Y, Tsabari R, Shenkman B, Schwartz R, Matetzky S, Lubetsky A, Orion D, Israeli-Korn S, Chapman J, Savion N, Varon D, Tanne D.
Aspirin responsiveness in acute brain ischaemia: association with stroke severity and clinical outcome.
Cerebrovasc Dis. (2008); 25(4):355-61.

Jilma-Stohlawetz P., Horvath M., Eichelberger B., Koren D., Jilma B., Panzer S.
Platelet function under high-shear conditions from platelet concentrates.
Transfusion (2008) 48: 129-135.

Oliver Meyer, Holger Kiesewetter, Abdulgabar Salama
Value of Platelet Function Testing in Monitoring Platelet Substitution
Transfusion Medicine Hemotherapy (2007) 34, 389–393

Simon Panzer, Lisa Höcker, Miriam Rieger, Rainer Vormittag, Daniela Koren, Daniela Dunkler, Ingrid Pabinger
Agonist-inducible platelet activation in chronic idiopathic autoimmune thrombocytopenia
European Journal of Haematology (2007) 79 (3), 198–204.

S. Panzer, M. Rieger, R. Vormittag, B. Eichelberger, D. Dunklerand I. Pabinger
Platelet function to estimate the bleeding risk in autoimmune thrombocytopenia
Eur J Clin Invest (2007) 37 (10): 814-819

Anand SX, Kim MC, Kamran M, Sharma SK, Kini AS, Fareed J, Hoppensteadt DA, Carbon F, Cavusoglu E, Varon D, Viles-Gonzalez JF, Badimon JJ, Marmur JD.
Comparison of platelet function and morphology in patients undergoing percutaneous coronary intervention receiving bivalirudin versus unfractionated heparin versus clopidogrel pretreatment and bivalirudin.
Am J Cardiol. (2007) Aug 1; 100(3):417-24

A. Morrison, V. S. Hornsey, C. V. Prowse & I. R. MacGregor
Use of the DiaMed Impact R to test platelet function in stored platelet concentrates.
Vox Sanguinis (OnlineEarly Articles). doi:10.1111/j.1423-0410.2007.00938.x

Ellinor I. Peerschke, Richard T. Silver, Babette B. Weksler, Wei Yin, Bernard Bernhardt, and David Varon
Examination of Platelet Function in Whole Blood Under Dynamic Flow Conditions With the Cone and Plate(let) Analyzer.
Am J Clin Pathol 2007;127:422-428

Simon Panzer, Beate Eichelberger, Daniela Koren, Karin Kaufmann, Christoph Male
Monitoring survival and function of transfused platelets in Bernard-Soulier syndrome by
flow cytometry and a cone and plate(let) analyzer (Impact-R).
Transfusion, 2007, Volume 47, Issue 1 January, Pages 103-106

L.E. Spieker, A.J. Flammer, N. Amacker, I. Sudano, J.J. Badimon, F. Ruschitzka, T.F. Lscher, G. Noll, R. Corti.
C-reactive protein influences shear stress-dependent platelet adhesion in patients with familiar
hypercholesterolemia and coronary artery disease undergoing LDL apheresis.
Thromb. Haemost. 96: 540-542, 2006.

A. Morrison, V. Hornsey, I. Macgregor.
Use of the DiaMed Impact R to Test Platelet Function in Stored Platelet Concentrates.
Transfusion Medicine 16:25, 2006.

R. Gerrah, A. Brill, S. Tshori, A. Lubetsky, G. Merin, D. Varon.
Using Cone and Plate(let) Analyzer to Predict Bleeding in Cardiac Surgery. Asian Cardiovasc.
Thorac. Ann. 14:310-315, 2006.

G. Yaron, A. Brill, O. Dashevsky, I. Mor Yosef-Levi, E. Grad, H. D. Danenberg, D. Varon.
C-reactive protein promotes platelet adhesion to endothelial cells: a potential pathway in atherothrombosis.
Br. J. Haematol. 134:426-431, 2006.

A. Maayan-Metzger, J. Kuint, A. Lubetsky, B. Shenkman, R. Mazkereth, G. Kenet.
Maternal selective serotonin reuptake inhibitor intake does not seem to affect neonatal platelet function tests.
Acta Haematol. 115:157-61, 2006.

Y. Levy-Shraga, A. Maayan-Metzger, A. Lubetsky, B. Shenkman, J. Kuint, U. Martinowitz, G. Kenet.
Platelet Function of Newborns as Tested by Cone and Plate(let) Analyzer Correlates with Gestational Age.
Acta Haematol. 115:152-156, 2006.

B. Shenkman, U. Budde, D. Angerhaus, A. Lubetsky, N. Savion, U. Seligsohn, D. Varon.
ADAMTS-13 regulates platelet adhesion under flow: A new method for differentiation between
inherited and acquired thrombotic thrombocytopenic purpura.
Thromb. Haemost. 96:160-166, 2006.

A. Solpov, B. Shenkman, Y. Vitkovsky, G. Brill, A. Koltakov, N. Farzam, D. Varon, I. Bank, N. Savion.
Platelets Enhance CD4+ Lymphocyte Adhesion to Extracellular Matrix under Flow Conditions:
Role of Platelet Aggregation, Integrins, and non-Integrin Receptors. Thromb. Haemost. 95:815-821, 2006.

Y. Hagaya, J. Lahav, A. Levanon, D. Varon, A. Brill, A. Panet.
Molecular characterization of an human monoclonal antibody that interacts with a sulfated tyrosine-containing
epitope of the GPIb receptor and inhibits platelet functions. Molecular Immunology 43:443-453, 2006.

F. Hermann, L.E. Spieker, F. Ruschitzka, I. Sudano, M. Hermann, C. Binggeli, T.F. Lscher, W. Riesen, G. Noll, R. Corti.
Dark chocolate improves endothelial and platelet function.
Heart 92;119-120, 2006.

Y. Levy, B. Shenkman, I. Tamarin, R. Pauzner, Y. Shoenfeld, P. Langevirtz, N. Savion, D. Varon.
Increased platelet deposition on extracellular matrix under flow conditions in patients with antiphospholipid syndrome
who experience thrombotic events. Arthritis & Rheum. 52:4011-4017, 2005.

G. Spectre, A. Brill, A. Gural, B. Shenkman, N. Turetzky, N. Savion, D. Varon.
A new point-of-care method for monitoring anti-platelet therapy: application of the Cone and Plate(let) Analyzer.
Platelets, 16: 293-299, 2005.

E. Kaluski, I. Malleihov, N. Savion, D. Varon, R. Winkler, Z. Vered, G. Cotter
Integrilin Dose Optimization Using Cone Plate Analyzer - What Have We Learned Thus Far.
Heart Drug 4:151-156, 2004.

EIB Peerschke, RT Silver, B Weksler, SE Grigg, N Savion, D Varon
Ex vivo evaluation of erythrocytosis-enhanced platelet thrombus formation using the cone and plate(let) analyzer:
effect of platelet antagonists. Br. J. Haematol., 127, 195-203, 2004.

R. Gerrah, E. Snir, A. Brill, D. Varon.
Platelet Function Changes as Monitored by Cone and Plate(let) Analyzer during Beating Heart Surgery.
Heart Surgery Forum 7 (3): E191-E195, 2004.

Spieker LE, Ruschitzka F, Badimon JJ, Noll G, Corti R
Shear stress-dependent platelet function after LDL cholesterol apheresis.
Thromb. Res. 113 (6): 395-398, 2004.

S. Wolberg, Z. Hong Meng, D.M. Monroe III, M. Hoffman.
A Systematic Evaluation of the Effect of Temperature on Coagulation Enzyme Activity and Platelet Function.
J. Trauma. 56:1221-1228, 2004.

S. Matetzky, B. Shenkman, V. Guetta, M. Shechter, R. Bienart, I. Goldenberg, I. Novikov, H. Pres, N. Savion, D. Varon, H. Hod.
Clopidogrel Resistance Is Associated With Increased Risk of Recurrent Atherothrombotic Events in Patients With Acute Myocardial Infarction.
Circulation 109:3171-3175, 2004.

B. Shenkman, A. Brill, G. Brill, O. Lider, N. Savion, D. Varon.
Differential response of platelets to chemokines: RANTES non-competitively inhibits stimulatory effect of
SDF-1. J. Thromb. Haemost. 2:154-160, 2004.

H. Hu, D. Varon, P. Hjemdahl, N. Savion, S. Schulman, N. Li.
Platelet-leukocyte aggregation under shear stress: Differential involvement of selectins and integrins.
Thromb. Haemost. 90: 697-687, 2003.

K. Jurk, K. J. Clemetson, P. G. de Groot, M. F. Brodde, M. Steiner, N. Savion, D. Varon, J. J. Sixma, H. Van Aken, B. E. Kehrel.
Thrombospondin-1 mediates platelet adhesion at high shear via glycoprotein Ib (GPIb):
an alternative/backup mechanism to von Willebrand factor. FASEB J. 17: U254-U271, 2003.

B. Shenkman, A. Inbal, I. Tamarin, A. Lubetsky, N. Savion, D. Varon.
Diagnosis of thrombotic thrombocytopenic purpura based on modulation by patient plasma of normal platelet
adhesion under flow condition. Brit. J. Haematol. 120: 597-604, 2003.

R. Dardik, B. Shenkman, I. Tamarin, R. Eskaraev, J. Harsfalvi, D. Varon, A. Inbal.
Factor XIII mediates adhesion of platelets to endothelial cells through avb3 and glycoprotein IIb/IIIa integrins.
Thromb. Res. 105:317-323, 2002.

Y. Finkelstein, B. Shenkman, L. Sirota, T.H. Vishne, R. Dardik, D. Varon, N. Linder.
Whole blood platelet deposition on extracellular matrix under flow conditions in preterm neonatal sepsis.
Eur J Pediatr 161: 270-274, 2002.

R. Dardik, N. Savion, N. Gal, D. Varon.
Flow conditions modulate homocysteine induced changes in the expression of endothelial cell genes associated with cell-cell
interaction and cytoskeletal rearrangement. Thromb. Haemost. 88: 1047-1053, 2002.

X.K. Wang, R.T. Dorsam, A. Lauver, H. Wang, F.A. Barbera, S. Gibbs, D. Varon, N. Savion, S.M. Friedman, G.Z. Feuerstein.
Comparative analysis of various platelet glycoprotein IIb/IIIa antagonists on shear-induced platelet activation and adhesion.
J. Pharmacol. Exp. Ther. 303: 1114-1120, 2002.

B. Shenkman, D. Varon, I. Tamarin, R. Dardik, M. Peisachov, N. Savion, E. Rubinstein.
Role of agr (RNAIII) in Staphylococcus aureus adherence to fibrinogen, fibronectin, platelets and endothelial cells under static and flow conditions.
J. Med. Microbiol. 51: 747-754, 2002.

C. Fallgren, A. Ljungh, B. Shenkman, D. Varon, N. Savion.
Venous shear stress enhances platelet mediated staphylococcal adhesion to artificial and damaged biological surfaces.
Biomaterials 23: 4581-4589, 2002.

N. Linder, B. Shenkman, E. Levin, L. Sirota, T. H. Vishne, I. Tamarin, R. Dardik, D. Lubin, N. Savion, D. Varon
Deposition of whole blood platelets on extracellular matrix under flow conditions in preterm infants.
Arch. Dis. Child. 86: F127-F130, 2002.

E.I. Lev, J.I. Osende, M.F. Richard, J.A. Robbins, J.A. Delfin, O. Rodriguez, S.K. Sharma, T. Jayasundera, J.J. Badimon, J.D. Marmur.
Administration of abciximab to patients receiving tirofiban or eptifibatide:
Effect on platelet function. J. Am. Coll. Cardio. 37: 847-855, 2001.

J.I. Osende, V. Fuster, E.I. Lev, D. Shimbo, U. Rauch, J.D. Marmur, M. Richard, D. Varon, J.J. Badimon.
Testing platelet activation with a shear-dependent platelet function test versus aggregation-based tests -
Relevance for monitoring long-term glycoprotein IIb/IIIa inhibition. Circulation 103: 1488-1491, 2001.

B. Shenkman, E. Rubinstein, A.L. Cheung, G.E. Brill, R. Dardik, I. Tamarin, N. Savion, D. Varon
Adherence properties of Staphylococcus aureus under static and flow conditions: Roles of agr and sar loci,
platelets, and plasma ligands. Infec. Immun. 69: 4473-4478, 2001.

B. Shenkman, J. Schneiderman, I. Tamarin, S. Kotev-Emeth, N. Savion, D. Varon.
Testing the effect of GPIIb-IIIa antagonist in patients undergoing carotid stenting: Correlation between standard aggregometry,
flow cytometry and the cone and plate(let) analyzer (CPA) methods. Thromb. Res. 102: 311-317, 2001.

N. Savion, B. Shenkman, I. Tamarin, R. Dardik, D. Varon.
Transient adhesion refractoriness of platelets under flow conditions: The role of partial activation and microaggregate
formation in controlling thrombus expansion. Brit. J. Haematol. 112: 1055-1061, 2001.

B. Shenkman, N. Savion, R. Dardik, I. Tamarin, D. Varon.
Testing of platelet deposition on polystyrene surface under flow conditions by the cone and plate(let) analyzer:
Role of platelet activation, fibrinogen and von Willebrand factor. Thromb. Res. 99:353-361, 2000.

Ariel, O. Lider, A. Brill, L. Cahalon, N. Savion, D. Varon, R. Hershkoviz.
Induction of interactions between CD44 and hyaluronic acid by a short exposure of human T cells to diverse
pro-inflammatory mediators. Immunology 100: 345-351, 2000.

A.G. Brill, B. Shenkman, G.E. Brill, I. Tamarin, R. Dardik, V.F. Kirichuk, N. Savion, D. Varon.
Blood irradiation by He-Ne laser induces a decrease in platelet responses to physiological agonists and an
increase in platelet cyclic GMP. Platelets 11:87-93, 2000.

B. Shenkman, E. Rubinstein, I. Tamarin, R. Dardik, N. Savion, D. Varon.
Staphylococcus aureus adherence to thrombin-treated endothelial cells is mediated by fibrinogen but not by platelets.
J. Lab. Clin. Med. 135:43-51, 2000.

R. Dardik, D. Varon, I. Tamarin, A. Zivelin, O. Salomon, B. Shenkman, N. Savion.
Homocysteine and oxidized low density lipoprotein enhance platelet adhesion to endothelial cells under flow
conditions: Distinct mechanisms of thrombogenic modulation. Thromb. Haemost. 83:338-344, 2000.

R. Dardik, D. Varon, R. Eskaraev, I. Tamarin, A. Inbal.
Recombinant fragment of von Willebrand factor AR545C inhibits platelet binding to thrombin and platelet
adhesion to thrombin-treated endothelial cells. Br. J. Haematol. 109:512-518, 2000.

Inbal, O. Gurevitz, I. Tamarin, R. Eskaraev, A. Chetrit, I. Novicov, M. Feldman, D. Varon, M. Eldar, J. Loscalzo.
Unique Antiplatelet Effects of a Novel S-Nitrosoderivative of a Recombinant Fragment of von Willebrand Factor,
AR545C: In Vitro and Ex Vivo Inhibition of Platelet Function. Blood, 94:1693-1700, 1999.

C. Yosefy, J.R. Viskoper, A. Laszt, R. Priluk, E. Guita, D. Varon, Z. Illan, E.M. Berry, N. Savion, Y. Adan, G. Lugassy, R. Schneider, A. Raz.
The effect of fish oil on hypertension, plasma lipids and hemostasis in hypertensive, obese, dyslipidemic patients with and without diabetes mellitus.
Prostaglandins Leukotrienes and Essential Fatty Acids 61:83-87, 1999.

B. Shenkman, N. Linder, N. Savion, I. Tamarin, R. Dardik, G. Kennet, B. German, D. Varon.
Increased neonatal platelet deposition on subendothelium under flow conditions:
The role of plasma von Willebrand factor. Pediatr. Res. 45:270-275, 1999.

B. Shenkman, E. Rubinstein, R. Dardik, I. Tamarin, N. Savion, D. Varon.
Activated platelets mediate Staphylococcus aureus deposition on subendothelial extracellular matrix:
the possibe role of glycoprotein Ib. Platelets 10:36-44, 1999.

O. Gurevitz, A. Goldfarb, H. Hod, M. Feldman, B. Shenkman, D. Varon, M. Eldar, A. Inbal
Recombinant von Willebrand Factor Fragment AR545C Inhibits Platelet Aggregation and Enhances
Thrombolysis With rtPA in a Rabbit Thrombosis Model. Arterioscler Thromb Vasc Biol. 18:200-207, 1998.

H. Knobler, N. Savion, B. Shenkman, S. Kotev-Emeth, D. Varon.
Shear-induced platelet adhesion and aggregation on subendothelium are increased in diabetic patients.
Thromb. Res. 90:181-190,1998.

R. Dardik, N. Savion, Y. Kaufmann, D. Varon.
Thrombin promotes platelet-mediated melanoma cell adhesion to endothelial cells under flow conditions:
role of platelet glycoproteins P-selectin and GPIIb-IIIa. Brit. J. Cancer 77:2069-2075, 1998.

G. Kenet, A. Lubetsky, B. Shenkman, I. Tamarin, R. Dardik, G. Rechavi, A. Barzilai, U. Martinowitz, N. Savion, D. Varon.
Cone and plate-let Analyzer (CPA): a new tool for the prediction of bleeding among thrombocytopenic patients.
Brit. J. Haematol. 101:225-259, 1998.

D. Varon, I. Lashevski, B. Brenner, R. Beyar, N. Lanir, I. Tamarin, N. Savion.
Cone and Plate(let) Analyzer: Monitoring glycoprotein IIb-IIIa antagonists and von Willebrand disease
replacement therapy by testing platelet deposition under flow conditions. Am. Heart J. 135: S187-S193, 1998.

D. Varon, D.E. Jackson, B. Shenkman, R. Dardik, I. Tamarin, N. Savion, P.J. Newman.
PECAM-1 serves as a co-stimulatory agonist receptor that modulates integrin-dependent
adhesion and aggregation of human platelets. Blood 91: 500-507, 1998.

D. Varon, R. Dardik, B. Shenkman, S. Kotev-Emeth, N. Farzame, I. Tamarin, N. Savion.
A new method for quantitative analysis of whole blood platelet interaction with extracellular
matrix under flow conditions. Thromb. Res. 85:283-294, 1997

R. Dardik, Y. Kaufman, N. Savion, N. Rosenberg, B. Shenkman, D. Varon.
Platelets mediate tumor cell adhesion to the subendothelium under flow conditions: involvement.
of platelet GPIIb-IIIa and tumor cell integrins. Int. J. Cancer 70:201-207, 1997.

C. Yosefy, J.R. Viskoper, D. Varon, Z. Ilan, D. Pilpel, G. Lugassy, R. Schneider, N. Savion, Y. Adan, A. Raz.
Repeated fasting and refeeding with 20:5, n-3 eicosapentaenoic acid (EPA): a novel approach for rapid
fatty acid exchange and its effect on blood pressure, plasma lipids and hemostasis.
J. Hum. Hypertens. 10: S135-S139, 1996.

Back to Top